A PRODUCTIVE EXPRESSION PLATFORM DERIVED FROM HOST-RESTRICTED EILAT VIRUS: ITS EXTENSIVE VALIDATION AND NOVEL STRATEGY

A Productive Expression Platform Derived from Host-Restricted Eilat Virus: Its Extensive Validation and Novel Strategy

Most alphaviruses are transmitted by mosquitoes and infect a wide range of insects and vertebrates.However, Eilat virus (EILV) is defective for infecting vertebrate cells at multiple levels of the viral life cycle.This host-restriction property renders EILV an attractive expression platform since it is not infectious for vertebrates and therefore p

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Age-preserved semantic memory and the CRUNCH effect manifested as differential semantic control networks: An fMRI study.

Semantic memory representations are overall well-maintained in aging whereas semantic control Belts is thought to be more affected.To explain this phenomenon, this study aims to test the predictions of the Compensation Related Utilization of Neural Circuits Hypothesis (CRUNCH) focusing on task demands in aging as a possible framework.The CRUNCH eff

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Mitochondrial Impairment in Sarcopenia

Sarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis.During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered and impinge on protein homeostasis, resulting in loss of muscle mass and function.Thus, 50 Ohm R

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